ea0019oc18 | Cardiovascular metabolism | SFEBES2009
Ahmed A
, Tomlinson J
, Dowman J
, Newsome P
, Elias E
, Wagenmakers A
, Stewart P
Non alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. The potential role of glucocorticoids (GC) in the pathogenesis of NAFLD, is highlighted by patients with GC excess, Cushings syndrome, who develop central adiposity, insulin resistance and in 20% of cases, NAFLD. Although in most cases of NAFLD, circulating cortisol levels are normal, hepatic cortisol availability is controlled by enzymes that regenerate cortisol from inacti...